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Percorten M: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Percorten M - General Information

Percorten M is a mineralocorticoid hormone and an analog of desoxycorticosterone. It is white, odorless, and stable in air. It is practically insoluble in water, sparingly soluble in acetone, slightly soluble in methanol, ether and vegetable oils. Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.

 

Pharmacology of Percorten M

Used to treat adrenocortical insufficiency, desoxycorticosterone pivalate is a mineralocorticoid hormone and an analogue of desoxycorticosterone. It primarily acts on the metabolism of sodium, potassium and water. When the drug is given, there is decreased excretion of sodium accompanied by increased excretion of potassium; the concentration of sodium in the blood is thereby increased whereas that of potassium is decreased. There is a concomitant increase in the volume of blood and extracellular fluids, with a fall in hematocrit. It increases the rate of renal tubular absorption of sodium.

 

Percorten M for patients

 

Percorten M Interactions

 

Percorten M Contraindications

Desoxycorticosterone Pivalate is contraindicated in patients with systemic fungal infections and in those with a history of possible or known hypersensitivity to this agent.

 

Additional information about Percorten M

Percorten M Indication

For treatment of adrenocortical insufficiency especially in multiple sclerosis, congenital cerebral palsy, polyarteritis nodosa, and rheumatoid arthritis.

Mechanism Of Action
Percorten M binds to the mineralocorticoid receptor. Mineralocorticoids are a family of steroids, secreted by the adrenal cortex, necessary for the regulation of a number of metabolic processes including electrolyte regulation. Desoxycorticosterone pivalate exerts its effect through its interaction with the mineralocorticoid receptor (MR), whereby it reacts with the receptor proteins to form a steroid-receptor complex. This complex moves into the nucleus, where it binds to chromatin which results in genetic transcription of cellular DNA to messenger RNA. The steroid hormones appear to induce transcription and synthesis of specific proteins, which produce the physiological effects seen after administration.
Generic Name
Desoxycorticosterone Pivalate
Synonyms
DOCP; Desoxycortone Pivalate; Desoxycorticosterone Trimethylacetate; Deoxycortone Trimethylacetate; Deoxycortone Pivalate; Deoxycortolone Pivalate; Deoxycorticosterone Trimethylacetate; Deoxycorticosterone Pivalate; DTMA
Drug Category
Diuretics; Anti-Addison Agents
Drug Type
Small Molecule; Approved
Other Brand Names containing Desoxycorticosterone Pivalate
Cortexone M; Neodin-Depositum; Percorten; Percorten M; Percorten Pivalate;
Toxicity (Overdose)
Symptoms of overdose include polyuria, polydipsia, increased blood volume, edema, and cardiac enlargement.
Protein Binding
90%
Chemical IUPAC Name
[2-(10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl)-2-oxoethyl] 2,2-dimethylpropanoate
Chemical Formula
C26H38O4
Organisms Affected
Humans and other mammals